The growing division between the Mono/Miaphysites and the Chalcedonians causes significant problems for the Eastern Empire, especially in Palestine and Egypt. In the West, Emperor Valentinian III is assassinated and Pope Leo I tries to keep the Vandals from destroying Rome.
Links:
Painting of Genseric sacking Rome by Bryullov.
Leo I’s letter to the monks of Palestine regarding his Tome
Chart showing the various Christological theologies and key representatives of each
Ernest Honigmann. “Juvenal of Jerusalem”. Dumbarton Oaks Papers. Vol. 5 (1950). pp. 209-279.
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#459 – A History of the Catholic Church – Rome Sacked Again